Dep-Pro (Deprenyl/Selegiline Hydrochloride Liquid) 1 mg 20 ml

Retail Price: $89.99 USD

Our Price: $84.95 USD


Deprenyl acts as a nerve and brain cell protector. Also known as Deprenyl Citrate (please note that the liquid we stock is the more thoroughly studied HCL version), Selegiline and Cyprenil, using Deprenyl can improve brain function, stimulate brain activity and effectively increase dopamine levels available in the brain. Used ‘off label’ to treat Alzheimer’s disease, its ability to prevent brain cell deterioration is well documented.

Deprenyl was originally developed as a ‘psychic energizer’, designed to integrate some amphetamine-like brain effects with anti-depressant effects. It has since been shown to protect nerve cells against a wide, and growing, number of neurotoxins, and has been shown to be a neuroprotection/neurorescue agent when nerve cells are exposed to damaging or stressful conditions.

Amongst the increasingly versatile discoveries of using Deprenyl - aside from its approved use for Parkinson’s disease, its ability to improve brain function and treat Alzheimer's disease – is the effect of extending life expectancy. With the power to increase dopamine levels, this reduces cell deterioration in key parts of the brain where dopamine is transmitted – prolonging lucidity and extending life expectancy potential.

Part of a group of medicine’s known as ‘smart drugs’ – Deprenyl belongs to a class of netraceuticals that are also called Nootropics. This category of supplements work to improve brain function, facilitate faster cognitive actions and improve concentration. Nootropics are also defined as drugs that are neuroprotective, non-toxic, and posses few side effects.

The graph opposite highlights the loss of dopamine with age, on average 13% per decade past the age of 40 for the average person, but far greater for those suffering from Parkinson’s disease.

The importance of dopamine in our brains

Involved in numerous cognitive functions, dopamine plays key roles in essential activity and emotions like: movement, motivation, desire, mood, attention span, learning and working memory. Dopamine levels decrease with age and decline more steeply after the age of 40. Preserving this quantity of available dopamine is therefore essential for ensuring youthful levels of brain activity.

Deprenyl as a preserver of dopamine levels

The nigrostriatal tract is the tiny Dopamine serving nerve cluster in the basal ganglia – a key connector and pathway to various parts of the brain. Professor Joseph Knoll – a key scientist in establishing various brain functions - emphasised that the nigrostriatal tract typically dies off at an average rate of 13% per decade starting at around age 45. By protecting this and lowering the death rate of the neurons in the nigostriatal tract, dopamine levels could be preserved and used in the brain effectively. How this links to human longevity is in the fact that the natural rate of deterioration of the basal ganglia would mean that the human lifespan can be set at 115 years, since by that age the nigral neuron population would have dropped below 10% of its original number. At this level, death would ensue regardless of other parts of the body remaining healthy.

Professor Knoll then went on to suggest that using Deprenyl from around aged 40 (when the decline begins to become rapid ), the nigostriatal neuron death rate could be lowered and life expectancy could therefore be increased in this respect. Couple this with the increased effectiveness of brain function in later life and a direct positive effect on quality of life is attained.

Deprenyl in wider medicine

Deprenyl has become acknowledged as an effective treatment for a variety of conditions like Parkinson’s disease and increasingly as a treatment for Alzheimer’s. Deprenyl also appears to be therapeutic and ameliorative in conditions such as: cerebral infarction a stroke ), hormone inadequacy, amyotrophic lateralizing sclerosis ( Lou Gherig's disease ), fatigue, chronic pain, gastric ulcers, senile dementia, sexual dysfunction, multiple sclerosis, learning difficulties, blepharospasm, hypertension, depression and cancer. It is also known to possess an aphrodisiac effect and helps to improve sexual function and desire.

Dosage Guidelines

Doses are normally around 2.5 mg to 5 mg once, twice or three times a week, or, 1 mg to 3 mg per day, with regular breaks. Deprenyl liquid can be titrated (calculated) precisely as each ml drop in the bottle is equivalent to 1 mg deprenyl citrate.

Deprenyl is an effective preserver of dopamine levels in the brain as well as a key cognitive enhancing smart drug – protecting nerve cells from an increasing number of neurotoxins, and providing the body with a powerful anti-aging remedy.

Side Effects

Possible gastrointestinal symptoms, such as nausea, heartburn, upset stomach, etc. Some studies have found side effects such as irritability, hyper-excitability, psychomotor agitation and insomnia. These effects are probably due to Deprenyl catecholamine-enhancing effect, over-activating DA/NA neural systems at the expense of calming/sleep-inducing serotonergic systems, so taking Magnesium and L-Tryptophan or 5HTP may suffice to counter these ‘psychic’ effects.

Supplement Facts

Serving Size: 1 drop
Servings Per Container: 300

  Amount Per
% Daily
Selegiline HCL 1 mg *
*Daily value not established

Other ingredients: Sterile water, potassium sorbate, lemon flavor, tropical punch flavor, flavor-sweet. (Flavors include purified water, glycerin, sorbitol, sodium saccharin, xanthan gum, FD&C red #40, FD&C yellow #6, citric acid, sodium citrate, methyl paraben, propylparaben, potassium sorbate).

Keep in cool dark conditions, out of the reach of children and consume before end of expiry date. Not for use by pregnant or lactating women.

These statements have not been evaluated by the FDA or Health Canada. This product is not intended to diagnose, cure or prevent disease.